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1987, Stenzel et al

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This activation of the NRF2/SLC7A11/GPX4 pathway enhanced GSH levels, decreased lipid ROS accumulation, inhibited ferroptosis and lipid peroxidation, and improved the cognitive functions of AD mice ( In summary, Ghrelin, Neuritin, GAA, and Artemisinin may mitigate cerebral neuronal injury and cognitive dysfunction by modulating neuronal ferroptosis, lipid peroxidation, the antioxidant system, oxidative stress, mitochondrial dysfunction, and neuroinflammation

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The muscle was digested in 1% collagenase in HBSS for 30 min at 37C with constant rotation