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Loss of GLP-2R action did not impact jejunal circumference or crypt depth (Supplementary Data 1), however, it significantly blunted the increase in jejunal villi length observed with cold stress compared to WT controls (Fig

(By 912 weeks, most pregnancies top out near ~288,000 mIU/mL, and typical levels at 5 weeks are only in the hundreds or low thousands.) Because hCG levels that high are so uncommon, the hook effect is a very rare exception rather than the rule