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111 A remaining question is whether potential controlling factors including allosteric control of glycogen synthase (GS) and phosphorylases via glucose-6-phosphate (G6P), 112 in addition to the insulin-independent transport of glucose across the hepatocellular plasma membrane by GLUT2 (as a glucose-sensitive protein in liver cells), can impact hepatic glycogen metabolism

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On one hand, melatonin could protect normal cells against ROS, preventing apoptosis

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Zhang, K., Zhou, Y., Feng, G

The above limitations may weaken the persuasiveness of our study, but the majority of eligible studies selected by 2 different investigators based on strict inclusion criteria were of high quality through a comprehensive literature search of 4 databases