In addition, recent studies have identified novel candidate genes, including C4A, which is involved in synaptic pruning and may influence the neurobiological mechanisms underlying depression [295]
GPx-1 may, therefore, diminish proliferative and survival signaling activated in response to cytokines, growth factors, or vasoactive substances that activate ROS-generating NOXs (9)
Importantly, the application of ferrostatin-1 successfully mitigated the ferroptosis and EMT-related dysfunctions, indicating promising pathways for therapeutic intervention ( Tumor protein p53 (TP53) , Enhancer of Zeste Homolog 2 (EZH2 ), Tissue inhibitor matrix metalloproteinase 1 (TIMP1) , Solute carrier family 3 member 2 (SLC3A2), and Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) (Zeng et al., 2025)
The synthesis of estrogen and the breakdown of estrogen are tightly regulated
Despite the development of these novel therapies, radiation therapy remains a critical tumor treatment 4,5
5.1.4 Endoplasmic reticulum stress Qian et al
