When deficiency is suspected based on clinical features (fatigue, paraesthesia, cognitive changes) or risk factors (vegan diet, gastric surgery, certain medications), serum B12 measurement guides appropriate intervention
If it isnt, they can stop
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Although structural insights into other FBXO22 native substrates are limited, our biochemical and cell-based data further support the notion that recruiting neosubstrates to the FBXO22 surface via degraders that engage Cys326 is unlikely to significantly perturb native substrate degradation
Rapidly separating dissolving microneedles with sustained-release colchicine and stabilized uricase for simplified long-term gout management
Ruminal escape, gastrointestinal absorption, and response of serum methionine to supplementation of liquid methionine hydroxy analog in dairy cows