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Ongoing phase 3 trials are in progress, and CagriSema is currently under FDA review, with a decision expected in late 2026

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The human gamma-glutamylcysteine synthetase enzyme is a dimer consisting of a heavy (catalytic) and a light (regulatory) subunit

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Blacker CJ, Millischer V, Webb LM, Ho AMC, Schalling M, Frye MA, et al

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ZIP7 resides on the ER membrane and releases zinc into the cytosol (following phosphorylation by CK2), thereby acting as a second messenger to activate signaling cascades such as AKT and ERK

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