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Pro-caspase-1 is recruited to the complex upon inflammasome assembly and undergoes autoproteolytic cleavage to generate active caspase-1

Konopleva M, Konoplev S, Hu W, Zaritskey AY, Afanasiev BV, Andreeff M

As already mentioned, GSTP1-1 is over-expressed in several cancers where it protects cells from cell death by inhibiting the activity of JNK or its upstream activation

The plasma stability of GLP-1MK-801 was optimized through incorporation of different cysteine homologues to the C terminus of the peptide to facilitate disulfide conjugation to the linker (Extended Data Fig

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SOD was extracted using 50 mM phosphate buffer (pH 7.8) containing 0.1% (w/v) ascorbate, 0.1% (w/v) BSA, and 0.05% (w/v) -mercaptoethanol