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Cross-Trial Context# Retatrutide's 24.2% weight loss at 48 weeks appears numerically superior to semaglutide's 14.9% at 68 weeks, but several factors complicate direct comparison: Trial phase : Phase 2 trials often yield more favorable results than Phase 3 (smaller, more controlled populations) Treatment duration : Semaglutide data are at 68-104 weeks

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doi: 10.1146/annurev-immunol-081619-104850 11 PollakNDlleCZieglerM

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