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(Wilding et al., NEJM, 2021 PubMed: 33567185) STEP 2 Trial (2021) In patients with both obesity and type 2 diabetes, semaglutide 2.4 mg produced mean weight loss of 9.6% versus 3.4% with placebo at 68 weeks

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Finally, a post-mortem analysis of human brain samples showed increased hippocampal expression of genes encoding for GLP-1R in individuals with severe alcohol-use disorder compared with controls 71

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Clinically IGF-1 is used to treat growth hormone deficiency, improves muscle strength and mobility especially in older women