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If you take the medicine away, your body reverts back to what it was doing." Velazquez said semaglutide and tirzepatide are part of a new class of medications that mark a turning point in treating obesity and chronic diseases associated with it

Clinical observations suggest that some patients experience changes in thyroid-stimulating hormone (TSH) levels after starting semaglutide, though the medication itself does not directly suppress or boost thyroid function

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Consistent with this interpretation, periodic acidSchiff (PAS) staining revealed a dramatic reduction in glycogen content in IR D707A/D707A livers (Fig

A 2023 head-to-head observational study published in JAMA Internal Medicine confirmed this real-world advantage, finding tirzepatide users lost significantly more weight than semaglutide users over comparable treatment periods

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