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In the anterior cingulate cortex, female MDD subjects showed reduced KYNA and lower KYNA/QA ratios compared to female controls, and those who died by suicide had lower KYNA compared to non-suicidal MDD subjects [65]

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Safety, Monitoring, and Provider-Guided Dosage Adjustment Glutathione is generally well-tolerated, though high oral doses may cause gastrointestinal discomfort