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Focusing on lean proteins, vegetables, fruits, and whole foods can improve tolerance and support successful weight loss

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The European Medicines Agency granted centralized approval in July 2011, but marketing authorization was withdrawn at the request of the sponsor in 2014 for commercial reasons (not safety)

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The fundamental difference is that orlistat prevents absorption of consumed calories from fat, whilst Wegovy reduces the desire to consume calories in the first place and improves metabolic efficiency