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Furthermore, our preliminary experiment revealed that long-term (12 weeks) supplementation of glutathione (50 mg/kg body weight) in mice did not significantly increase liver glutathione levels compared to than in controls, indicating that oral administration of glutathione does not significantly affect the glutathione levels in the liver, when sufficient amounts of glutathione can be synthesized

you are simply presenting the opportunity at a consistent time until the body begins to anticipate and respond to it," says Birch

N Engl J Med (2006) 354:178795