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Some clinicians avoid the DAC form for this reason, reserving it for patients who find daily injections prohibitive

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Finally, we review mechanismbased strategiesincluding KRAS G12C inhibitors, effluxpump antagonists, apoptosis reactivators, and epigenetic/autophagy modulatorsand propose an integrated, multimodal regimen leveraging immunotherapy where appropriate, informed by real-time drug sensitivity data (e.g., from liquid biopsy), dynamic biomarkers and AIdriven optimization to overcome resistance and improve patient outcomes