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If you're experiencing moderate to severe sleep disruption during perimenopause, it's worth discussing HRT with a menopause-informed healthcare provider who can assess your individual risk profile and help you make an informed decision

10.1016/j.drudis.2018.01.016 161 MalaviyaR.MorrisonA

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Patients should be aware that: No licensed combination product exists in the UK Any combination use would be considered experimental and is not supported by current evidence Clinical decisions must be guided by a qualified healthcare professional with access to current trial data Clinical Evidence and Trial Data Available to UK Patients Retatrutide Phase 2 data showed approximately 24% mean body weight reduction at the highest dose over 48 weeks, but no published trial data exist for the specific cagrilintideretatrutide combination

378 A small clinical trial involving 18 patients with IBS found adhering to personalized food restrictions based on reactions to food reintroductions after a short-term low-FODMAP diet resulted in lasting symptom relief after one year in 12 of the participants