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[11], comparing semaglutide plus SGLT-2i with placebo

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Obese individuals have up to a fourfold higher risk of developing it, especially in weight-bearing joints such as the knees and hips

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The need to study this phenomenon is particularly crucial for agents like semaglutide and liraglutide, which have demonstrated profound weight loss but also significant regain after cessation, as observed in the STEP 4 and SCALE trials [13,14]

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