In the future, we will develop small molecule inhibitors or activators for specific transporters such as SLC25A39 and xCT, and use gene editing tools (such as CRISPR/Cas9) to precisely edit related genes to achieve precise regulation of GSH metabolism, providing more targeted means for disease treatment
Oral GLP-1 rivals now have a huge opportunity if they can show a cleaner safety profile and can avoid the liver toxicity profile that impacted Pfizer's #danuglipron
GLP-1 has also been considered an anorexigenic peptide, while also reducing cerebral glucose metabolism in the human hypothalamus and brain stem
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Compounded peptides are sometimes offered when branded medications are expensive or in short supply, but the FDA has warned that compounded semaglutide and tirzepatide may not meet the same safety or quality standards as FDA-approved products (FDA statement on compounded semaglutide)