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[8] [9] The risk of low blood sugar increases meaningfully only when these agents are combined with insulin or sulfonylureas

Abbreviations DPP4: Dipeptidyl peptidase 4 GLP-1: Glucagon-like peptide-1 SGLT2: Sodiumglucose cotransporter 2 References Cosentino F, Grant PJ, Aboyans V et al (2020) 2019 ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

An alternative treatment option may be necessary in such cases based on the clinical condition

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Clinical Evidence Supporting Dual-Therapy Combinations Real-world clinical practice increasingly supports metformin-tirzepatide combinations, particularly in patients with elevated A1C levels and significant weight to lose

There are also several distinctions