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The thirty seconds it takes to update your reference card can prevent the kind of dosing error that sends people to the emergency room

We constrained the binding pocket as defined by all residues within a specified distance to the substrate in a crystal structure, and we constrained evolutionarily conserved residues that may be important for function

These lower doses were not part of the studies that led to FDA approval

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Moderately stable: Medium-length peptides (15 to 50 amino acids) including tirzepatide, semaglutide, and most therapeutic peptides