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[2] Mazdutides phase II trial in adults with obesity or excess weight showed approximately 10-14% weight loss at 4 mg and 6 mg doses over 32 to 48 weeks, with ongoing phase III trials investigating higher doses and effects on type 2 diabetes

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This triad promotes the release of pro-inflammatory cytokines and induces a predominant Th1-mediated immune response characteristic of Hashimotos thyroiditis (HT)