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No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern

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However, as with any supplement or medication, some side effects can occur

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It has also been used in sports to improve performance

This process enhances fat oxidation, making it easier for the body to burn stubborn fat