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In terms of the immune response, our secretome analysis revealed enrichment of immune-related pathways under oxidative stress, with qPCR confirming increased expression of inflammatory mediators IL-6, IL-11, and IL-18 shortly after H 2 O 2 treatment

Basically, Nox15, using NADPH as a substrate, produces superoxide anions that can be quickly converted to other ROS, whereas DUOX1 and DUOX2 specifically produce hydrogen peroxide [144]

Knocking out this gene promotes ferroptosis and inhibits prostate cancer cell growth [56]

Greater intrafollicular IGF-2 levels can explain why a 1.6-fold elevation in intrafollicular IGF-1 lacks any impact on follicular maturation in primates [13]

RNA-seq and analysis Total RNA isolation, cDNA library construction, and sequencing were performed at BGI (Beijing Genomics Institute, Shenzhen, Guangdong, China) using RNA-seq technology, as previously described 77,78

Psychosomatic Medicine 61(5):591-598