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More rigorous clinical trials are required to assess efficacy, safety, and tolerability

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When mature IGF-I lacking any E-peptide extension was expressed virally, it failed to increase muscle mass, whereas the E-peptide-bearing IGF-IA and IGF-IB isoforms drove hypertrophy evidence that, in this system, the E-domain is necessary for the local anabolic effect rather than being an inert appendage

They inhibit reactive oxygen species (ROS) formation and reduce endothelial dysfunction by upregulating nitric oxide production

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During the course of the studies, animal health, body weight, and mortality were monitored and recorded