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1999b;31:S121127

The tirzepatide ODT format has gained some traction as an alternative to both liquid drops and injections, though it faces the same fundamental bioavailability challenges

The body naturally creates them in the small intestine to trigger insulin secretion and prevent glucagon secretion

Semaglutide and tirzepatide are medications in the class of glucagon-like peptides (GLP-1s), making them one option in the class of the most effective FDA approved treatments for weight loss

The tradeoff is lower bioavailability compared to injectable semaglutide

Nishinaka T, Kodaka R, Nanjo H, Terada T, Mizoguchi T, Nishihara T