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Leukotriene E4induced pulmonary inflammation is mediated by the P2Y12 receptor

Nasal spray protocol: Dose: 200-500 mcg per application Frequency: 1 to 2 times daily Duration: 4 to 8 weeks Nasal delivery is particularly interesting for researchers focused on neurological applications, as the nasal route provides a potential pathway to bypass the blood-brain barrier through the olfactory and trigeminal nerve pathways

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The mobile phase A was 97% water and 3% ACN (20 mM NH 4 Ac, 15 mM NH 4 OH, pH = 9.0), and the mobile phase B was 100% ACN

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