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The medication may be allowed to reach room temperature before administration if stored under refrigeration, as cold injections may be more painful and could potentially affect absorption kinetics

This may last a few hours, but might also stay for up to a week

The Institute of Medicine reports that no adverse effects have been associated with excess vitamin B12 intake from food, supplements, or injections in healthy individuals. Nevertheless, its crucial to consult a professional before beginning any high-dosage supplement

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Endocrine Journal , 59(7), 529538

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