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Improves insulin sensitivity: A 2025 meta-analysis of 17 randomized controlled trials involving nearly 6,000 women found that HRT significantly reduced insulin resistance (HOMA-IR) in healthy postmenopausal women [8]

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30 On the other hand, restoring sleep health is an important part of treatment for mental health disorders through its ability to regulate stress signaling, reduce brain inflammation, and improve neuroplasticity

However, semaglutide has its own advantages, including a longer track record of safety data, wider availability, and lower cost in many cases

Instead, PT-141 acts directly on the nervous system , particularly by activating melanocortin receptors in the brain