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Nonetheless, direct evidence is still missing

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The result in phase 2 clinical trials was 24.2% mean body weight reduction at 48 weeks with the 12mg dose, and the first phase 3 TRIUMPH-4 trial reported an average of 28.7% weight loss at 68 weeks

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For weight management, NHS treatment is typically initiated within specialist weight management services, with specific BMI thresholds, comorbidity requirements, and continuation criteria that must be met

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Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, et al

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Results emerge subtly over 48 weeks and can last up to two years or more

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