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Government price negotiation The BALANCE model established a precedent for direct government negotiation with GLP-1 manufacturers

For type 2 diabetes , NICE NG28 recommends continuing GLP-1 treatment only if there is adequate response, defined as HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight at 6 months

And never leave medication out for more than the manufacturer recommended time, typically 14 to 28 days depending on the formulation

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At therapeutic doses used for diabetes or moderate weight management, the anti-inflammatory effects may predominate

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