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It is believed that a products effect on FPG level is directly related to pharmacokinetics of GLP-1 RA and GLP-1 receptor activation pattern, which, in turn, leads to the differential secretion of insulin and glucagon during a fasting state [107]

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Scientific American notes that glycogen is stored with water, which explains why some early weight loss is water weight rather than fat loss. Cleveland Clinic explains that starting with too large of a calorie deficit can lead to side effects such as fatigue, nausea, dehydration, constipation, headaches, and irritability. These symptoms are signals that energy intake may not be matching the bodys current needs

The answer starts at the cellular level