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In the 2023 study, 80 percent of participants who took oral semaglutide for weight loss experienced gastrointestinal problems compared with 46 percent of those who took a placebo

M.BugianesiE.et al (2025)

Gene knockdown experiments further revealed that SiO-induced ferroptosis and ROS elevation are mediated by NOX4 upregulation and Smad3 activation, highlighting the critical role of ferroptosis and this signaling axis in SiO-induced intraocular pressure elevation

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