Metabolic rebound after GLP-1 reception agonist discontinuation This new meta-analysis compiled data from 18 studies (3771 participants) to establish the effects of discontinuing use of GLP-1 receptor agonists on metabolic outcomes Here are the main findings In adults with obesity, discontinuing GLP-1 receptor agonists use led to significant Weight regain (+5.63 kg) Increase in HbA1c (+0.25%) Plus increased waist circumference, BMI, systolic blood pressure and fasting plasma glucose In adults with diabetes, discontinuing GLP-1 receptor agonists use led to significant Weight regain (+2.03 kg) Increase in HbA1c (+0.65%) Weight regain was also greater with a longer follow-up period, indicating that weight regain continues to rise the longer the period of discontinuation This meta-analysis highlights key aspects of GLP-1 receptor agonist use: 1 GLP-1 receptor agonists use may only be a long term strategy to support weight loss (if you start, you stay using it) 2 You must combine GLP-1 receptor agonists use with behavioural interventions to support weight loss outcomes (diet and exercise) 3 You cannot rely of GLP-1 receptor agonists alone over the short term, and expect to maintain any metabolic and/or weight loss outcomes Reference: Subscribe to Performance Nutrition Digest FREE to receive your daily study breakdown, straight to your inbox or via the Substack app Performance Nutrition Digest is powered by Healthspan Elite GLP-1 Receptor Agonist Discontinuation Effects on Metabolism Metabolic rebound after GLP-1 reception agonist discontinuation This new meta-analysis compiled data from 18 studies (3771 participants) to establish the effects of discontinuing use of GLP-1 receptor agonists on metabolic outcomes Here are the main findings In adults with obesity, discontinuing GLP-1 receptor agonists use led to significant Weight regain (+5.63 kg) Increase in HbA1c (+0.25%) Plus increased waist circumference, BMI, systolic blood pressure and fasting plasma glucose In adults with diabetes, discontinuing GLP-1 receptor agonists use led to significant Weight regain (+2.03 kg) Increase in HbA1c (+0.65%) Weight regain was also greater with a longer follow-up period, indicating that weight regain continues to rise the longer the period of discontinuation This meta-analysis highlights key aspects of GLP-1 receptor agonist use: 1 GLP-1 receptor agonists use may only be a long term strategy to support weight loss (if you start, you stay using it) 2 You must combine GLP-1 receptor agonists use with behavioural interventions to support weight loss outcomes (diet and exercise) 3 You cannot rely of GLP-1 receptor agonists alone over the short term, and expect to maintain any metabolic and/or weight loss outcomes Reference: Subscribe to Performance Nutrition Digest FREE to receive your daily study breakdown, straight to your inbox or via the Substack app Performance Nutrition Digest is powered by Healthspan Elite To view or add a comment, sign in More Relevant Posts Vitamin B12 Deficiency Definition: Vitamin B12 deficiency is a condition caused by insufficient vitamin B12, leading to impaired DNA synthesis, megaloblastic anemia, and neurological dysfunction
Additionally, Pinealons action on neuroprotective and cellular repair pathways helps alleviate stress by stabilizing neuronal activity, enhancing mood, and promoting a sense of well-being, which can improve emotional resilience and sleep quality
I am a proponent of using GLP-1s for weight loss when done responsibly and in a way that sets the patient up for long-term success (i.e., a healthy lifestyle that allows them to maintain their weight post-medication)
Mioduchoski, FNP-BC One of the most common questions men ask is whether BPC-157 affects testosterone levels, hormone production, fertility, muscle growth, or sexual performance
View product TB-500 (Thymosin Beta-4) facilitates actin-mediated cell migration and stem cell recruitment, enabling cellular execution of the repair program
This inefficient process produces excessive lactic acid, alters cellular pH, and causes microscopic muscle damage that can take days or weeks to repair
