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CO 291/9-2, CO 291/10-2, CO 291/14-1) and the CRC TRR 353 (CO 291/11-1, #471011418), the German Federal Ministry of Education and Research (BMBF) FERROPATH (01EJ2205B) and the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation programme (grant agreement No

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Concurrently, GSH reduces Fe 3 + to Fe 2 + , which activates S 2 O 8 2 to generate highly toxic sulfate (SO 4 ) and hydroxyl radicals, inducing coordinated ferroptosis and pyroptosis in lung cancer cells 219

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5.3.3 Ferroptosis in coronary microvascular dysfunction Coronary microvascular dysfunction, a distinct pathological entity within the spectrum of coronary heart disease, involves significant ferroptotic endothelial cell death

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