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Chemotherapy 27 (Suppl

Reactions included nausea, vomiting, chills, low blood pressure, difficulty breathing , and in some cases, possible bloodstream infection

Avoid doubling the dose

This combined effect of metformin on glycerol-3-phosphate dehydrogenase, substrate inhibition, and GLP-1 secretion makes it an essential therapeutic option for controlling hepatic gluconeogenesis and maintaining glucose homeostasis in individuals with insulin resistance or T2DM (He et al., 2009)

A maximum of 3 grams daily

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