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Compound heterozygosity produces more pronounced impairment than either variant alone

Increased circulating fibronectin, depletion of natural IgM and heightened EBV, HSV-1 reactivation in ME/CFS and long COVID

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The present study ACHIEVE-3 was a 52-week, non-inferiority, open-label, active-control, randomised, phase 3 trial comparing orforglipron 12 mg or 36 mg versus oral semaglutide 7 mg or 14 mg (Rosenstock et al, 2026)

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