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Nevertheless, redox cycling remains an understated mechanism of toxicity due to the fleeting existence of free radical intermediates which hinders their quantification in real time, both in vitro and in vivo 6

& MacLennan, I

Under iron-catalytic conditions, maintenance of the Fe 2 + /Fe 3 + redox couple promotes extensive peroxidation of PUFA-containing membrane phospholipids and drives ferroptotic execution in cancer cells 190,191

Poole, L.B

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