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Methods We obtained the data from PubMed, Scopus, Embase, and Web of Science for all eligible studies, including clinical trials (RCT) and cohorts comparing GLP-1 RAs to placebo or other hypoglycemic agents in patients with HFpEF published until December 31st, 2024

While GLP-1 medications are highly effective, their side effects can present obstacles

7 Discussion GLP-1 RAs have shown effects beyond their initial application in managing T2DM

Baseline: 2 to 3 litres daily Training days: Closer to 3.7 litres, depending on your activity level First thing in the morning: About 500ml within 30 minutes of waking up That morning, your body loses fluid overnight, and GLP-1 medication can make morning nausea worse on an empty, dehydrated stomach

Traditional SMGT-GLP-1 treatments , such as semaglutide injections , work quickly but require frequent administration

Incidence rate ratios (IRRs) of malignancy in patients with type 2 diabetes mellitus (DM): glucagon-like peptide-1 receptor agonist (GLP-1 RA) group vs