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showed that in head and neck cancer cell line HSC-3 PLC activation through RhoA-GTP can be blocked by overexpression of PZD domain of leukemia Rho-GEF (LARG) protein, suggesting that PZD domain of LARG can be a potential inhibitor of RhoA/PLC-mediated production of inositol-3-phosphates, release of Ca 2+ from internal storages and thus starting the cascade of signaling events involved in development of head and neck cancer [54]

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NAC (N-Acetylcysteine) NAC boosts glutathione production, a critical antioxidant for liver functioning

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