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So thats part of it

During the early stages of APAP-induced liver injury, stressed and damaged hepatocytes release various endogenous DAMPs, such as HMGB1, 75 nuclear DNA fragments, 76 uric acid, 77 mitochondrial DNA, 76 ATP, and heat shock protein-70, an inducible stress response protein that is translocated to the cell surface and released during cellular stress or necrotic death

Integrative Cancer Therapies, 6 (2), 146-157

Similarly, PDE4 inhibitors (e.g., Roflumilast) reduce inflammation by modulating cyclic AMP (cAMP) signaling

Peptides are getting a lot of attention in hair loss medicine right now