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When taken concurrently, the additive effect on the cardiovascular system requires baseline and periodic monitoring of blood pressure and pulse to ensure these levels remain within a safe therapeutic range

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Novo Nordisk said that PIONEER TEENS is the first clinical trial of an oral GLP-1 in this age group, and could become an important new option for T2D patients of this age "who require glycaemic control beyond that provided by the current standard of care." There are also limitations with the current treatment options, as metformin is unable to achieve blood glucose control targets in approximately half of adolescents, while basal insulins can have side effects, including low and potentially dangerous blood glucose levels (hypoglycaemia) and weight gain

Tirzepatide has a different side effect profile, and many people who struggled with semaglutide find tirzepatide more tolerable, though the reverse can also be true