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As organoids and other NAMs gain momentum, one of the most critical challenges is no longer just building advanced models, but making them reproducible, standardized, and scalable for real-world drug development

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Furthermore, adding to the complexity of this process, allosteric activators have been described that bind to sites distinct from the orthosteric binding pocket of the receptor (Zhao et al., 2020), thereby necessitating a highly precise preselection of compounds to be used as lead candidates

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