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The most common typically strongest in the first 48 weeks as the body adapts include: Nausea (most common, usually dose-dependent) Diarrhoea or constipation Fatigue , especially during dose escalations Mild headache Reflux and acid reflux Loss of appetite (this is the therapeutic effect, not a side effect, but it can be uncomfortable) Less common but more serious effects warranting immediate physician review include pancreatitis, gallbladder disease, and kidney issues, particularly in patients with pre-existing conditions

Vomiting: Some patients may experience vomiting along with nausea, especially when they first begin taking semaglutide or when their dosage is increased

Exposure to semaglutide appeared to be greater in the treatment arms that employed longer pre-dose fasting periods (Figs

This can make things tough even for those who try their best

The longer it stays above 46 degrees, the more degradation occurs

Further, the studies employed 2 estimands in their statistical analyses