While previous studies have shown that CNS GABAergic neurons are necessary for the food intake- and body weight-reducing effects of GIPR agonists 5,11 , the anatomic region that underlies these effects remains unknown
Research tools not widely available clinically
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However, additional research is necessary to ensure these findings are reproducible, and the durability of fasting-induced weight loss without ongoing therapeutic support remains uncertain
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Importantly, hemodynamic effects - modest reductions in heart rate (+2-4 bpm) and blood pressure decreases - are generally well tolerated and beneficial in this population