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Radioiodine carries the risk of exacerbating Graves orbitopathy and so is best avoided in patients with significant thyroid eye disease

Footnotes:

The SURPASS-2 study included a total of 1878 patients with T2D who were receiving a background of metformin therapy, with an HbA1c of 7.0% to 10.5%, and were randomized to one of the four treatment arms

doi: 10.1007/BF02694482

Clinical trials demonstrate that participants using semaglutide consume roughly 20% fewer calories than baseline without deliberate caloric restriction, suggesting the appetite suppression occurs at a physiological rather than behavioral level