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Conflict of interest The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

This study was approved by the Ethics Committee of the Heidelberg University (S-119/2017)

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Crushing or chopping garlic and allowing it to rest for 5-10 minutes before cooking activates enzymes that produce beneficial sulfur compounds, potentially enhancing its glutathione-supporting effects

For example, the TRPA1-specific agonist cinnamaldehyde significantly inhibits ferroptosis in cellular and animal models by activating CaMKII phosphorylation and Nrf2 nuclear translocation [87]

Compared to healthy individuals, MS patients, both with and without calciphylaxis, exhibit elevated basal expression levels of hypoxia-related proteins (GLUT1 and VEGF), with the highest levels observed in those with calciphylaxis (182)