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A 2021 study published in The Lancet found that while GLP-1 drugs were effective for many, their success varied based on factors such as genetic predisposition, underlying medical conditions, and adherence to lifestyle modifications

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Kuna RS, Girada SB, Asalla S, Vallentyne J, Maddika S, Patterson JT, Smiley DL, DiMarchi RD, Mitra P: Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic ncreatic