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Kaler SG

Hypertension, defined as a systolic pressure of 130 mm Hg or higher, or a diastolic pressure of 80 mm Hg or higher, is a robust predictor of future incidence of stroke, coronary heart disease, heart attack, heart failure, and cardiovascular-related death

Clinical trials show average weight loss of 15-20% of body weight over 68 weeks with semaglutide (Wegovy) and 15-22% with tirzepatide (Zepbound)

Where they really shine is in combinations that stretch the nutritional value further

Feeling unusually cold is not a primary listed side effect in clinical trials, but many patients report it during active weight loss on GLP-1 therapy

S4) between neurons and glia contributes 50-60% of glutamate neurotransmitter (12, 13, 20) with intracellular sources such as glycolysis supplying the remainder