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Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, de Ferranti SD, Floyd J, Fornage M, Gillespie C, Isasi CR, Jimnez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Mackey RH, Matsushita K, Mozaffarian D, Mussolino ME, Nasir K, Neumar RW, Palaniappan L, Pandey DK, Thiagarajan RR, Reeves MJ, Ritchey M, Rodriguez CJ, Roth GA, Rosamond WD, Sasson C, Towfighi A, Tsao CW, Turner MB, Virani SS, Voeks JH, Willey JZ, Wilkins JT, Wu JH, Alger HM, Wong SS, Muntner P (2017) Heart disease and stroke statistics-2017 update: a report from the American Heart Association

The cancer chemotherapy drug methotrexate is used in Crohns patients that are steroid dependent or have not responded to glucocorticoids (Preiss 2010)

Cardiovascular wellness is inseparable from metabolic health

Inadequate protein intake below 0.8 grams per kilogram of body weight per day accelerates muscle breakdown, which further reduces metabolic rate and deepens fatigue

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nevertheless, all of the other GLP-1s are being used off-label for patients who desire GLP-1 treatment