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Rotate injection sites to minimize skin irritation and avoid injecting into areas with broken or bruised skin

Published Phase 2 data (NEJM, 2023) showed retatrutide achieving up to 24.2% mean weight reduction at 48 weeks exceeding outcomes seen with dual GLP-1/GIP agonists

Summary: Retatrutide may offer women benefits including substantial weight reduction and improvements in metabolic markers, but it remains an unlicensed investigational medicine in the UK with no approved prescribing guidance yet available

The same medication produces opposite bowel effects in different people, which is a strong hint that the mechanism is about motility and transit rather than about irritation

To ascertain whether plasma and liver FGF21 could act on endocrine pancreas, we analysed the single-cell RNA sequencing data of in vitro differentiation of beta cells [24] (available in the public database GSE114412)

So, although they belong to the same family, theyre usually used in different contexts