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These effects are generally dose-related and often improve with gradual dose escalation

PMID 30261596

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Two highly conserved glutamic acid residues in the predicted beta propeller domain of dipeptidyl peptidase IV are required for its enzyme activity

Collectively, our data identify a series of tesaglitazar targets in the hypothalamus and show that the GLP-1RA/tesaglitazar conjugate improves body weight, food intake and glucose metabolism with superior efficacy relative to treatment with the GLP-1RA, tesaglitazar or the fixed dose combination of GLP-1RA and tesaglitazar

This is a significant dose